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Affinity Maturation of Monoclonal Antibody 1E11 by Targeted Randomization in CDR3 Regions Optimizes Therapeutic Antibody Targeting of HER2-Positive Gastric Cancer.

机译：通过靶向随机化在CDR3区域中单克隆抗体1E11的亲和力成熟优化靶向HER2阳性胃癌的治疗性抗体。

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作者
Bong-Kook Ko; Soyoung Choi; Lei Guang Cui; Young-Ha Lee; In-Sik Hwang; Kyu-Tae Kim; Hyunbo Shim; Jong-Seo Lee;
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年度 2015
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入库时间 2022-08-20 21:13:17

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1. Combination of novel HER2-targeting antibody 1E11 with trastuzumab shows synergistic antitumor activity in HER2-positive gastric cancer [J] . Bong-Kook Ko, Sook-Yeon Lee, Young-Ha Lee, Molecular oncology. . 2015,第2期

机译：新型靶向HER2的抗体1E11与曲妥珠单抗的组合在HER2阳性胃癌中显示出协同的抗肿瘤活性
2. Affinity maturation by targeted diversification of the CDR-H2 loop of a monoclonal Fab derived from a synthetic naive human antibody library and directed against the internal trimeric coiled-coil of gp41 yields a set of Fabs with improved HIV-1 neutralization potency and breadth. [J] . Gustchina E, Louis JM, Frisch C Virology . 2009,第1期

机译：通过衍生自合成的天然人抗体文库并针对gp41的内部三聚体卷曲螺旋的单克隆Fab的CDR-H2环的靶向多样化，进行亲和力成熟，可以生产出具有改善的HIV-1中和力和广度的Fab。
3. Granulocyte-macrophage colony-stimulating factor (GM-CSF) as a therapeutic target in psoriasis: randomized, controlled investigation using namilumab, a specific human anti-GM-CSF monoclonal antibody [J] . Papp K. A., Gooderham M., Jenkins R., British Journal of Dermatology . 2019,第6期

机译：粒细胞 - 巨噬细胞殖民地刺激因子（GM-CSF）作为牛皮癣的治疗靶标：使用Namilumab的随机，受控调查，一种特异的人抗GM-CSF单克隆抗体
4. Selection of Monoclonal Antibodies Targeting Therapeutic Membrane Proteins Through a Cell-Based Phage Display Panning System [C] . Yu Jung Kim, Bin Yoo, Yoonji Kim, Protein Engineering Summit. . 2018

机译：通过基于细胞的噬菌体展示平移系统靶向治疗膜蛋白的单克隆抗体的选择
5. Design, synthesis and validation of Axl-targeted monoclonal antibody probe for microPET imaging of human lung cancer. [D] . Guo, Jiacong. 2013

机译：针对人类肺癌的microPET成像的Axl靶向单克隆抗体探针的设计，合成和验证。
6. Affinity Maturation of Monoclonal Antibody 1E11 by Targeted Randomization in CDR3 Regions Optimizes Therapeutic Antibody Targeting of HER2-Positive Gastric Cancer [O] . Bong-Kook Ko, Soyoung Choi, Lei Guang Cui, -1

机译：通过在CDR3区域中靶向随机化单克隆抗体1E11的亲和力成熟可优化靶向HER2阳性胃癌的治疗性抗体。
7. Combination of novel HER2-targeting antibody 1E11 with trastuzumab shows synergistic antitumor activity in HER2-positive gastric cancer. [O] . Ko, Bong-Kook, Lee, Sook-Yeon, Lee, Young-Ha, 2015

机译：新型HER2靶向抗体1E11与曲妥珠单抗的组合在HER2阳性胃癌中显示出协同的抗肿瘤活性。
8. Monoclonal Antibodies and Cancer. Studies on the Use of Monoclonal Antibodies for Imaging and Therapy of Cancer, with Special Emphasis on Ovarian Carcinoma [R] . Haisma, H. J. 1987

机译：单克隆抗体和癌症。单克隆抗体在癌症成像和治疗中的应用研究，特别强调卵巢癌

Affinity Maturation of Monoclonal Antibody 1E11 by Targeted Randomization in CDR3 Regions Optimizes Therapeutic Antibody Targeting of HER2-Positive Gastric Cancer.

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